Plastic pollution has emerged as a major environmental threat, particularly in the ASEAN region, where it impacts marine resources crucial to AMS economies. As AMS depend on marine ecosystems, plastic pollution poses significant risks to their ocean economies and biodiversity. This policy brief emphasises the importance of regional knowledge sharing as a strategy to effectively address plastic pollution. Drawing insights from initiatives such as the ASEAN Conference on Combating Plastic Pollution: Enhanced Synergies and Collaborative Actions to Combat Plastic Pollution (ACCPP 2023), it argues that collaborative knowledge sharing enables AMS to coordinate actions, share best practices, and create harmonised responses to the challenges posed by plastic pollution in marine environments.